Brain-Targeted Black Phosphorus-Based Nanotherapeutic Platform for Enhanced Hypericin Delivery in Depression.

Depression is a significant global health concern that remains inadequately treated due to the limited effectiveness of conventional drug therapies. One potential therapeutic agent, hypericin (HYP), is identified as an effective natural antidepressant. However, its poor water solubility, low bioavailability, and limited ability to penetrate the brain parenchyma have hindered its clinical application. To address these shortcomings and enhance the therapeutic efficacy of HYP, it is loaded onto black phosphorus nanosheets (BP) modified with the neural cell-targeting peptide RVG29 to synthesize a nanoplatform named BP-RVG29@HYP (BRH). This platform served as a nanocarrier for HYP and integrated the advantages of BP with advanced delivery methods and precise targeting strategies. Under the influence of 808 nm near-infrared irradiation (NIR), BRH effectively traversed an in vitro BBB model. In vivo experiments validated these findings, demonstrating that treatment with BRH significantly alleviated depressive-like behaviors and oxidative stress in mice. Importantly, BRH exhibited an excellent safety profile, causing minimal adverse effects, which highlighted its potential as a promising therapeutic agent. In brief, this novel nanocarrier holds great promise in the development of antidepressant drugs and can create new avenues for the treatment of depression.

A framework for prioritizing urban ecological infrastructure (UEI) implementation tasks based on residents' ecological demands and government policies.

With rapid urbanization, balancing urban ecological infrastructure (UEI) construction and residents' ecological demands (RED) has become an imperative but challenging issue for sustainable development. This study develops an integrated framework to systematically prioritize UEI implementation based on localized RED and government policies. We incorporate the Kano model and quality function deployment (QFD) approach to quantify the complex associations between various resident needs and existing policies. Taking Chengdu City as a case study, resident surveys and policy reviews are conducted to construct the demand-policy linkage matrix and determine the importance of UEI tasks. Results reveal that, (1) flood control capacity is most prioritized by RED, followed by wetland area and less PM2.5, while cultural service demands rank lower; (2) Forest coverage, green space development, wetland construction and park construction emerge as priority UEI implementation tasks that can maximize fulfilling RED. This novel framework enables adaptive customization of UEI planning for different cities through configurable modeling. It provides a valuable decision support tool that enables optimizing or improving the prioritization of UEI implementation tasks based on residents' preferences. The research results have important reference value for the prioritization of UEI implementation tasks.

Analysis of the Impact of Landscape Patterns on Urban Heat Islands: A Case Study of Chengdu, China.

The urbanization process, such as population growth and the expansion of roads, railways, residential areas, and industrial areas, causes severe landscape fragmentation and changes in the surface temperature balance, resulting in the heat island effect. This study used Landsat data to study the impact of landscape patterns on urban heat islands (UHIs) and temporal-spatial change characteristics. In addition, spatial correlation analysis was employed to detect the relationships between land surface temperature (LST) and landscape patterns. The results showed that the impervious surfaces landscape area increased significantly, and the Woodland landscape area increased. However, the bare land, cropland, and water body area decreased. The cohesion of cropland and woodland landscape in the suburb decreased, and there was a high degree of fragmentation. The difference between the contributions of the central city and suburbs to the whole region is narrowing, and the expansion of urban heat islands is shifting from the central city to the suburbs. The percentage of landscape index (PLAND) and the patch cohesion index (COHESION) of woodland, water body, and cropland were negatively correlated with LST. Meanwhile, the PLAND and COHESION of impervious surface and bare land were positively correlated with LST, and the splitting index (SPLIT) was the opposite of the PLAND and COHESION. The fragmentation of impervious surfaces and bare land landscapes reduces the UHI effect. Based on these results, countermeasures to mitigate the heat island effect are proposed. These measures will play an essential role in improving urban ecology and the environmental quality of human settlements.

Improving the Communication and Credibility of Government Media in Response to Public Health Emergencies: Analysis of Tweets From the WeChat Official Accounts of 10 Chinese Health Commissioners.

Background: A significant public health emergency has appeared worldwide since the beginning of 2020. The spread of negative information about COVID-19 on social media poses a challenge and threat to public health disposition and the credibility of government public opinion. Objective: This study aimed to analyze the rules and characteristics of government media in disseminating information on public emergencies. In addition, find ways and means to improve government media's communication power and credibility. Method: Based on relevant theories and measures of information econometrics, 10 WeChat official accounts of the Chinese government were taken as examples. The Python crawler tool was used to collect data of 10 WeChat official accounts-related tweets. In addition, this study used various tools, such as ROST, UCINET, and SPSS, for statistical analysis and co-word analysis of the data. Result: From January 17 to March 31, 2020, 6,612 COVID-19-related tweets were published by 10 WeChat official accounts, which broadcast epidemic overview, epidemic prevention and control, science and disinformation, epidemic assistance, epidemic impact, and negative impact. By analyzing the posting time and content of the tweets, we found that changes in the number of articles posted by the WeChat and changes in content and the progress of the COVID-19 pandemic are nearly synchronized, and most tweets are published at 8:00 am. Furthermore, based on the analytics of high dissemination index and high-frequency words, we propose that there is a significant correlation between the strength of independence and the credibility of the WeChat official account. Conclusion: The three elements of WeChat communication (value, interest, and moving) and the degree of independent innovation of public numbers impact the communication power and credibility of government media. First, if the articles published by the WeChat official account are valuable, interesting, and moving, the communication power of the WeChat official account would get more powerful. Second, increased ability for independent innovation has a positive impact on enhancing the WeChat official account's credibility. Third, government media can improve its governance effects of public health emergencies by enhancing their communication power and credibility.

Assessment of Urban Agglomeration Ecological Sustainability and Identification of Influencing Factors: Based on the 3DEF Model and the Random Forest.

The evaluation of ecological sustainability is significant for high-quality urban development and scientific management and regulation. Taking the Chengdu urban agglomeration (CUA) as the research object, this paper combined the three-dimensional ecological footprint model (3DEF) and random forest to evaluate the ecological sustainability of the study area and identify the influencing factors. The study results indicate that: (1) From 2000 to 2019, the ecological sustainability of Chengdu urban agglomeration was divided into four types, and the overall ecological sustainability of this region showed a downward trend. The areas with higher ecological sustainability were mainly distributed in the northern part of the urban agglomeration (Mianyang City) and the southern part (Leshan City and Ya'an City), while the cities in the central region (Chengdu City, Meishan City, and Ziyang City) had lower ecological sustainability. (2) The main factors affecting the ecological sustainability of urban agglomerations are industrial wastewater discharge, industrial smoke (powder) dust discharge, and green coverage of built-up areas, followed by urbanization and population size. Through this study, we have two meaningful findings: (a) Our research method in this paper provides a new way to study the factors affecting the ecological sustainability of urban agglomerations. (b) The results of the identification of influencing factors might be the reference for urban environmental infrastructure construction and urban planning.

Impact of Land Use/Cover Change on Yangtze River Delta Urban Agglomeration Ecosystem Services Value: Temporal-Spatial Patterns and Cold/Hot Spots Ecosystem Services Value Change Brought by Urbanization.

Land use/cover change (LUCC) from increased urbanization significantly impacts regional ecosystem services. Based on a cold/hot spots analysis, this paper used grain yield, food prices, price index statistics, and a land use thematic map to study the impact of LUCC on four ecosystem services values (ESVs) in the Yangtze River Delta urban agglomeration, and determine the spatial differences resulting from the rapid urbanization LUCC. The correlation between the four ecosystem services was then studied and sensitivity analyses conducted to investigate whether any changes in the ESVs could lead to unacceptable unit value transfer uncertainties. It was found that most urban land was converted from farmland, and that before 2000, the total ESVs and the regulating services values (RSVs) increased significantly, after which it declined, the provisioning services values (PSVs) declined year on year, the habitat services value (HSV) and cultural and amenity services value (CSV) declined sharply after 2000, and the spatial distribution of the four ESVs were significantly different. Over time, it was found that the hot spots were shrinking and the cold spots were spreading. The provisioning services were found to be negatively correlated with habitat services and cultural and amenity services, the regulating services were weakly positively correlated with the provisioning services and significantly positively correlated with the habitat services and cultural and amenity services, and the habitat services were significantly positively correlated with cultural and amenity services. In the Yangtze River Delta urban agglomeration, the water area is the most important for the total ESVs, followed by non-bush forest. Paddy field is ranked third. Dryland, bush, grassland, and wetland are less important. The importance of barren land is almost zero. This research provides the government with a scientific basis from which to formulate spatial planning and environmental protection policies for ecological sustainable development in the Yangtze River Delta urban agglomeration.